Nonequilibrium gating of CFTR on an equilibrium theme.
نویسندگان
چکیده
Malfunction of cystic fibrosis transmembrane conductance regulator (CFTR), a member of the ABC protein superfamily that functions as an ATP-gated chloride channel, causes the lethal genetic disease, cystic fibrosis. This review focuses on the most recent findings on the gating mechanism of CFTR. Potential clinical relevance and implications to ABC transporter function are also discussed.
منابع مشابه
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ورودعنوان ژورنال:
- Physiology
دوره 27 6 شماره
صفحات -
تاریخ انتشار 2012